PO-05-186 LEVERAGING A NATURAL EXPERIMENT TO DETERMINE THE EFFECT OF AIR POLLUTION ON VENTRICULAR ARRHYTHMIAS AND PHYSICAL ACTIVITY: THE 2020 U.S. WILDFIRES

Particulate matter (PM) air pollution is associated with atherosclerotic cardiovascular disease. While the biological processes that link PM exposure to disease may also trigger arrhythmias, there are limited data on association of ventricular arrhythmias. The high levels as a consequence 2020 U.S. wildfires provide unique opportunity explore effects cardiac physical activity, and heart failure markers using device remote monitoring data. To evaluate failure. We performed retrospective cohort study CERTITUDE database patients Biotronik CIEDs. included at least one transmission or after 1/1/2020. primary predictors were Air Quality Index (AQI), < 10 μm in diameter (PM10), 2.5 (PM2.5). evaluated continuous binary variables for values ≧ 90th percentile calendar year. determined day-level pollutant US EPA cross-linked patients’ Zip codes proxy patient location, we examined outcomes interest listed Table. (1) case-crossover analysis conditional logistic regression model followed by (2) time-varying an Andersen-Gill day level air-pollutant exposure. 28349 (32% female, age 72.8±11.9), whom 1822 (6.4%) had loop recorders, 17448 (61.6%) pacemakers, 9079 (32%) defibrillators. In analysis, AQI PM2.5 demonstrated non-significant trends toward higher ATP shocks (Table). significant but non-meaningful associations change rate, activity thoracic impedance. (ORs 0.99-1). contrast prior literature ambient pollution, these natural experiment analyses did not demonstrate acute sub-acute between AQI, PM2.5, PM10 CIED patients. Mediators findings merit further investigation clarify causal non-causal mechanisms.